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The Substance

If you follow the instructions, what could go wrong?

7.3

282 votes
Release07 Sep, 2024
Runtime141 min
Budget $17,500,000.00
Revenue $16,846,463.00
  • Horror
  • Drama
  • Science Fiction

STORY

A fading celebrity decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself.

TRAILERS

Official Clip - Lucky Day

Official Clip - Pump It Up With Sue

Breaking Down THE SUBSTANCE's Shrimp Scene

The hype is real

TIFF 2024 Q&A

Mark it in your calendar

Official Trailer

Official Teaser

Official Clip

CAST

  • Demi Moore

    Demi Moore

    Elisabeth Sparkle
  • Margaret Qualley

    Margaret Qualley

    Sue
  • Dennis Quaid

    Dennis Quaid

    Harvey
  • Edward Hamilton-Clark

    Edward Hamilton-Clark

    Fred
  • Gore Abrams

    Gore Abrams

    Oliver
  • Christian Erickson

    Christian Erickson

    Man at Diner
  • Robin Greer

    Robin Greer

    Male Nurse
  • Hugo Diego Garcia

    Hugo Diego Garcia

    Diego
  • Olivier Raynal

    Olivier Raynal

    Alan
  • Tiffany Hofstetter

    Tiffany Hofstetter

    The Stylist
  • Tom Morton

    Tom Morton

    The Doctor
  • Jiselle Burkhalter

    Jiselle Burkhalter

    Girl
  • Axel Baille

    Axel Baille

    The Photographer
  • Oscar Lesage

    Oscar Lesage

    Troy
  • Matthew Géczy

    Matthew Géczy

    Bob Haswell
  • Philip Schurer

    Philip Schurer

    Mr. Scream
  • Daniel Knight

    Daniel Knight

    Casting Director
  • Namory Bakayoko

    Namory Bakayoko

    Silhouette
  • Bill Bentley

    Bill Bentley

    Suit
  • Lucie Laffin

    Lucie Laffin

    Woman from the Public
  • Gregory Defleur

    Gregory Defleur

    Happy Birthday Person
  • Vincent Colombe

    Vincent Colombe

    Suit
  • Yann Bean

    Yann Bean

    “The Substance” (voice)