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The Substance

If you follow the instructions, what could go wrong?

7.3

758 votes
Release07 Sep, 2024
Runtime141 min
Budget $17,500,000.00
Revenue $29,106,531.00
  • Horror
  • Drama
  • Science Fiction

STORY

A fading celebrity decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself.

TRAILERS

Official Clip - Lucky Day

Breaking Down THE SUBSTANCE's Shrimp Scene

The hype is real

TIFF 2024 Q&A

Mark it in your calendar

Official Trailer

Official Teaser

Official Clip

CAST

  • Demi Moore

    Demi Moore

    Elisabeth
  • Margaret Qualley

    Margaret Qualley

    Sue
  • Dennis Quaid

    Dennis Quaid

    Harvey
  • Edward Hamilton-Clark

    Edward Hamilton-Clark

    Fred
  • Gore Abrams

    Gore Abrams

    Oliver
  • Oscar Lesage

    Oscar Lesage

    Troy
  • Christian Erickson

    Christian Erickson

    Man at Diner
  • Robin Greer

    Robin Greer

    Male Nurse
  • Tom Morton

    Tom Morton

    Doctor
  • Hugo Diego Garcia

    Hugo Diego Garcia

    Diego - Boyfriend
  • Daniel Knight

    Daniel Knight

    Casting Director
  • Jonathon Carley

    Jonathon Carley

    Assistant Casting Director
  • Jiselle Henderkott

    Jiselle Henderkott

    Girl Auditioning
  • Akil Wingate

    Akil Wingate

    TV Host
  • Vincent Colombe

    Vincent Colombe

    Man in Suit #1 - Harvey's Office
  • Billy Bentley

    Billy Bentley

    Man in Suit #2
  • Lennard Ridsdale

    Lennard Ridsdale

    Man in Suit #3
  • Jordan Ford Silver

    Jordan Ford Silver

    Assistant Director - Pump It Up Show
  • Oscar Salem

    Oscar Salem

    2nd Assistant Director - Pump It Up Show
  • Viviane Bossina

    Viviane Bossina

    Sue's Assistant
  • Matthew Luret

    Matthew Luret

    Floor Runner
  • Jana Bittnerová

    Jana Bittnerová

    Maria
  • Olivier Raynal

    Olivier Raynal

    Alan - 2nd Agent
  • Tiffany Hofstetter

    Tiffany Hofstetter

    Stylist
  • Nicolas Royer

    Nicolas Royer

    Guy in the Elevator
  • Nathan Rippy

    Nathan Rippy

    Assistant Director - New Year's Eve Show
  • Manon Arizmendi

    Manon Arizmendi

    Little Girl - New Year's Eve Show
  • Virginie Kotlinski

    Virginie Kotlinski

    Mother - New Year's Eve Show
  • Brett Gillen

    Brett Gillen

    Director of Photography - New Year's Eve Show
  • Charlotte Marquardt

    Charlotte Marquardt

    Screaming Woman
  • Léa Hengl

    Léa Hengl

    Screaming Woman
  • Gaëlle Raymond

    Gaëlle Raymond

    Screaming Woman
  • Claire Lemaire

    Claire Lemaire

    Screaming Woman
  • Lila Boughoufala

    Lila Boughoufala

    Screaming Woman
  • Aurélien Lorgnier

    Aurélien Lorgnier

    Screaming Man
  • Ivan Sellier

    Ivan Sellier

    Screaming Man
  • Philip Schurer

    Philip Schurer

    Screaming Man
  • Christian Bourmier

    Christian Bourmier

    Shareholder
  • Martin Graham

    Martin Graham

    Shareholder
  • Christian Bordeleau

    Christian Bordeleau

    Shareholder
  • Patrick Hamel

    Patrick Hamel

    Shareholder
  • Didier D'Hondt

    Didier D'Hondt

    Shareholder
  • Jacques-Yves Dorges

    Jacques-Yves Dorges

    Shareholder
  • Jean-Claude Matthey

    Jean-Claude Matthey

    Shareholder
  • Olivier Jarcin

    Olivier Jarcin

    Shareholder
  • Jean-Luc Magneron

    Jean-Luc Magneron

    Shareholder
  • Charlotte Murray

    Charlotte Murray

    Allison - Diner Waitress
  • Aaron Kahn

    Aaron Kahn

    Greeting Person
  • Gabriela Arnon

    Gabriela Arnon

    Greeting Person
  • Nancy Josephson Lahoussine

    Nancy Josephson Lahoussine

    Greeting Person
  • Andrew Eldridge

    Andrew Eldridge

    Greeting Person
  • Denise Powers

    Denise Powers

    Greeting Person
  • Bryan Jones

    Bryan Jones

    Greeting Person
  • Adam Carage

    Adam Carage

    Happy Birthday Person
  • Maria McClurg

    Maria McClurg

    Happy Birthday Person
  • Andrew Desmond

    Andrew Desmond

    Happy Birthday Person
  • Rebecca Lafont

    Rebecca Lafont

    Happy Birthday Person
  • Laura Puech

    Laura Puech

    Isabella
  • Ryan Chidester

    Ryan Chidester

    Stagehand
  • Céline Vogt

    Céline Vogt

    Elisabeth (Young) - Walk of Fame
  • Yannick Guérin

    Yannick Guérin

    Clumsy Burger Guy - Walk of Fame
  • Jean Miel

    Jean Miel

    Worker Walk of Fame
  • Paul Descoings

    Paul Descoings

    Worker Walk of Fame
  • Benoit Lévêque

    Benoit Lévêque

    Worker Walk of Fame
  • Arthur Molinet

    Arthur Molinet

    Cocktail Bartender
  • Manon Sachot

    Manon Sachot

    Cocktail Lounge Couple
  • Bastien Jorelle

    Bastien Jorelle

    Cocktail Lounge Couple
  • Kelly Hoarau

    Kelly Hoarau

    Female Assistant - Towel
  • Michel Juskiewicz

    Michel Juskiewicz

    George - Harvey's Friend
  • Louise Greggory

    Louise Greggory

    Restaurant Waitress
  • Christophe Sartirano

    Christophe Sartirano

    Guy Looking at Sue
  • Florent Torres

    Florent Torres

    Guy Looking at Sue
  • Romain Caldeira

    Romain Caldeira

    Billboard Technician
  • Barthelemy Thomas

    Barthelemy Thomas

    Billboard Technician
  • Axel Baille

    Axel Baille

    Photographer
  • Ashley Lambert

    Ashley Lambert

    Additional Voices
  • Ranjani Brow

    Ranjani Brow

    Additional Voices
  • Chase Fein

    Chase Fein

    Additional Voices
  • Shane Sweet

    Shane Sweet

    Additional Voices
  • William Calvert

    William Calvert

    Additional Voices
  • Michael Corbett

    Michael Corbett

    Additional Voices
  • Stephen Apostolina

    Stephen Apostolina

    Additional Voices
  • Yann Bean

    Yann Bean

    The Substance (voice)
  • Matthew Géczy

    Matthew Géczy

    Bob Haswell (uncredited)
  • Namory Bakayoko

    Namory Bakayoko

    Silhouette (uncredited)
  • Gregory Defleur

    Gregory Defleur

    Happy Birthday Person (uncredited)